大骨节病患儿与非患儿血中硒和巯基关系的对比研究

测定了大骨节病患儿血浆总巯基，非蛋白巯基．蛋白结合巯基和全血硒含量，并与病区非患儿和非病区儿童进行对比研究．结果表明，大骨节病重病区儿童（包括患儿组和非患儿组）体内三种血浆巯基和血硒含量都低于消退病区及非病区儿童，而以大骨节病患儿组下降最明显（Ｐ＜０．０１或＜０．０５）。血硒与三种巯基的相关分析仅在大骨节病患儿组显示出有意义的正相关关系．说明大骨节病患儿血浆巯基的减少与硒缺乏有关，提示患儿体内抗氧化防御系统受损。

Comparative study on relationship between blood selenium and sulfhydryl groups in children with and without Kashin-Beck disease

The total plasma sulfoydryl groups, nonprotein and protein-bound sulfhydryl groups as well as blood Se were determined in the children with and without Kashin-Beck disease (KBD) from two KBD affected and a non-affected areas. The results showed that the contents of three-type sulfhydryl groups and Se reduced in the children from the severe KBD affected area, especially in the children with KBD,compared with those from the non-affected area and the endemic area in which few new cases had been found for recent years (P less than 0.01 or 0.05). There were significantly POsitive correlations between blood Se contents and the contents of three-type sulfhydryl groups only in KBD group. These data indicate that the decrement of plasma sulfhydryl groups in KBD group is related to Se deficiency, suggesting that the children with KBD have the impairment of antioxidant protective systems.