上海市人群甲型流感病毒H1、H3、H5、H9抗体血清学监测

目的 ]　了解上海市人群对甲 3型、甲 1型流感病毒和禽流感病毒H9、H5的抗体 ,探讨甲 3型、甲 1型流感流行的趋势和禽流感病毒H9、H5抗体存在情况。　 方法 ]　应用常规血凝抑制试验微量半加敏法对上海市不同年龄组人群进行甲型流感抗体血清学监测。　 结果 ]　对A/SH/1/98(H3N2 )毒株的抗体阳性率为 96.2 0 % ;对A/SH /7/99(H1N1)毒株的抗体阳性率为 72 .60 % ;对H9毒株的抗体阳性率为 7.5 6% ;对H5毒株的抗体阳性率仅 0 .75 %。　 结论 ]　A/SH/1/98(H3N2 )类毒株已不可能在上海再度引起流行 ;A/SH/7/99(H1N1)类毒株今后在人群中 ,特别在 0～ 4岁年龄组中可能存在散在性发生或局限性小爆发 ;本市人群曾受到禽流感H 9病毒的感染 ,不能排除由本市禽类中的H9病毒感染及人的可能 ;受禽流感H5毒株感染只是个别现象。禽流感病毒在本市禽类中的感染状况及对人的影响需进一步研究

Serological surveillance on antibody to influenza A subtype H1, H3, H5, H9 viruses in people of Shanghai

To explore the epidemic trend of influenza A3, A1 and the existent situation of antibodies to avian influenza H9,H5 viruses through studying the distribution of antibodies to influenza A(H1,H3,H5,H9)viruses in people of different age groups in Shanghai. From healthy people at Huangpu,Jiading,Nanhui and Pudong district of Shanghai in June 2002,500 serum samples were taken and divided into 5 groups according to people's ages:0～4,5～14,15～24,25～59,≥60yr,100 samples per group. The titers of antibodies to influenza A(H1,H3,H5,H9)viruses were detected by hemagglutination-inhibition test. HI titer≥20 is considered positive,the total positive rate of HI titer of antibody to influenza viruses A/SH/1/98(H3N2),A/SH/7/99(H1N1) was 96.20%,72.60% respectively. Meanwhile,a certain positive rate of HI titer of antibody to avian influenza H9 virus was also detected in every age group,with total positive rate 7.56%. Only two serum samples with antibody to avian influenza H5 virus were detected. One was detected from 25～59 age group, HI titer was 80.The other from ≥60,HI titer was 40. The total positive rate was only 0.75%. Conclusion] It's impossible that A/SH/1/98(H3N2)-like virus could arise an epidemic again in Shanghai in the following years. It is possible that A/SH/7/99(H1N1) like virus could arise limited epidemic and scattered cases,especially in 0～4 age group in Shanghai. People were infected by avian influenza H9 virus in Shanghai,so the possibility of transmisson of the influenza H9 virus from local aves to people could not be excluded. Only few people were infected by avian influenza H5 virus in Shanghai,may be very small quatity of H5 virus existed in aves of Shanghai. Therefore,the situation of local aves infected by avian influenza viruses and their influence to people should be further studied. We suggest that some avian or animal influenza virus antigens should be added in serological surveillance on antibody to influenza virus in people.