头针对手术期氧化应激反应调节能力的观察

目的探讨头针对手术期氧化应激反应的调节作用。方法选择需做肠癌根治术的患者52例,随机分为两组,头针加全麻组(简称头针组)和单纯全麻组(简称全麻组)各26例。头针组患者先行头针麻醉诱导20min,然后行全身麻醉,头针麻醉持续刺激至手术结束。全麻组只行单纯气管内全麻。观察头针对手术期氧化应激产物丙二醛(MDA),氧自由基清除剂超氧化物歧化酶(SOD)的影响。结果两组在术后MDA均明显降低(P<0.05),手术前后MDA的差值组间差异无显著性意义(P>0.05);头针组术后SOD无明显变化(P>0.05),全麻组术后SOD明显降低(P<0.05),手术前后SOD的差值组间差异有显著性意义(P<0.05)。结论头针可抑制抗氧化防御系统酶SOD的降低,因此头针对减轻手术期的氧化应激反应有一定的作用。

Effects of scalp acupuncture on regulative ability of oxidative stress reaction at operation stage

Objective To study on regulative action of scalp acupuncture on oxidative stress reaction at operation stage. Methods Fifty-two cases selected for radical operation of intestinal cancer were randomly divided into a scalp acupuncture plus general anesthesia (scalp acupuncture group) and a simple general anesthesia group (general anesthesia group), 26 cases in each group. The scalp acupuncture group were treated first with scalp acupuncture for 20 min, followed by general anesthesia, with scalp acupuncture lasted till the end of operation. The general anesthesia group were treated only with simple intratracheal anesthesia. Effects of scalp acupuncture on malondialdehyde (MDA) level and superoxide dismutase (SOD) activity at the operation stage were observed. Results After operation, MDA levels decreased significantly (P<0.05) in the two groups, but with no difference between the two groups in the different values of MDA before and after treatment (P>0.05); there was no significant change in SOD before and after treatment in the scalp acupuncture group, and significantly decreased in the general anesthesia group (P<0.05). There was a significant difference between the two groups in the different value of SOD before and after the operation (P<0.05). Conclusion Scalp acupuncture can inhibit the decrease of SOD activity, reducing oxidative stress reaction at operation stage.