Survivin与TSLP在子宫腺肌病中的表达及意义

目的：检测抑凋亡蛋白Survivin与胸腺基质促淋巴细胞生成素（TSLP）在子宫腺肌病中的表达，探讨Survivin与TSLP在子宫腺肌病发生发展中的关系。方法：采用免疫组化法检测子宫腺肌病中 Survivin 和TSLP的表达情况，分析两者与子宫腺肌病的关系。结果：Survivin在增生期和分泌期子宫腺肌病的表达，均高于正常子宫内膜，差异具有统计学意义（增生期t＝20．239，P＜0．01；分泌期t＝17．852，P＜0．01）。TSLP在增生期和分泌期子宫腺肌病的表达，均高于正常子宫内膜，差异具有统计学意义（增生期t＝17．983，P＜0．01；分泌期t＝13．975，P＜0．01）。在子宫腺肌病增生期和分泌期中Survivin与TSLP的表达呈现正相关（增生期r＝0．732；分泌期r＝0．716）。结论：子宫腺肌病患者的内膜组织中存在Survivin和TSLP的异常高表达，两者在子宫腺肌病的发生及发展过程中有着一定的联系。

Expression and significance of Survivin and TSLP in the adenomyosis

Objective:To detect the expression of Survivin and TSLP in adenomyosis.To investigate the relation-ship between Survivin and TSLP in the development of adenomyosis.Methods:The expression of TSLP and Survivin in the patients with adenomyosis were detected by immunohistochemical method and analyze the relationship of them with the uterine gland.Results:The expression of Survivin in proliferative phase and secretory phase was significantly higher than that in normal endometrium,the difference was statistically significant (proliferative phase t=20.239,P<0.01,secretory phase t=17.852,P<0.01).The expression of TSLP in proliferative phase and secretory phase was significantly higher than that in normal endometrium,the difference was statistically significant (proliferative phase t=17.983,P<0.01,secretory phase t=13.975,P<0.01).The expression of and Survivin was positively correlated with the expression of TSLP in the proliferative phase and the secretory phase (proliferative phase r=0.732,secretory phase r=0.716).Conclusion:High expression of Survivin and TSLP in adenomyosis was found.There is a certain re-lationship between the two in the occurrence and development of adenomyosis.