调强适形放疗致老年食管癌放射性肺损伤的相关因素分析

目的：分析接受调强适形放疗老年食管癌患者中发生放射性肺损伤的相关因素。方法：回顾分析接受调强适形放疗的86例老年食管癌患者的临床资料，包括患者年龄、性别、卡氏评分、T 分期、吸烟史、基础肺疾病、病变部位、肺平均剂量 MLD、双肺 V5、V10、V20及 V30等因素。结果：在86例老年食管癌患者中，有17例发生放射性肺损伤。单因素分析显示，放射性肺损伤与高龄、卡氏评分、基础肺疾病、肺平均剂量 MLD、双肺V5、V10、V20及 V30因素有相关性。结论：老年食管癌患者进行调强放疗时，应充分考虑高龄、卡氏评分、基础肺疾病、肺平均剂量 MLD、双肺 V5、V10、V20及 V30因素，预测和减少发生放射性肺损伤的风险。

Analysis of factors of radiation -induced lung injury with IMRT for elderly esophageal car-cinoma patients

Objective:To analyze the factors of radiation -induced lung injury with IMRT for elderly esophageal carcinoma patients.Methods:The clinical data of 86 elderly esophageal carcinoma patients received IMRT were retro-spectively reviewed,including age,gender,performance status scoring,T staging,smoking history,underlying disease of the lung,tumor location,mean lung dose(MLD),lung receiving 5,10,20,and 30Gy(V5 ,V10 ,V20 and V30 ,respec-tively).Results:Among 86 patients,17 developed radiation injury.It was revealed by univariate analysis that there were significant differences in age,performance status scoring,underlying disease of the lung,mean lung dose(MLD), lung receiving 5,10,20,and 30Gy(V5 ,V10 ,V20 and V30 ,respectively)with radiation injury (P <0.05).Conclusion:It should be payed more attention to factors such as age,performance status scoring,underlying disease of the lung, mean lung dose(MLD),lung receiving 5,10,20 and 30Gy when elderly esophageal carcinoma patients were treated with IMRT in order to prevent and decrease the risks of radiation -induced lung injury.