三阴性乳腺癌与PARP1表达相关性的Meta分析

目的：评价PARP1（poly ADP－ribose polymerase 1）表达与三阴性乳腺癌的临床相关性。方法：计算机检索PUBMED、CNKI、万方数据库，同时辅助其他检索，收集所有关于PARP1在三阴性乳腺癌组织中表达关系的相关文献，应用Cochrane协作网RevMan 5．2软件对满足条件的数据进行统计分析。结果：最终纳入5篇文献，共700例病人，其中三阴性乳腺癌331例，非三阴性乳腺癌369例。Meta分析结果显示：与非三阴性乳腺癌相比，PARP1在三阴性乳腺癌中的表达差异具有显著统计学意义（OR＝3．24，95％CI：1．45～7．23，P＝0．004）。结论：PARP1的表达与三阴性乳腺癌呈正相关关系，或可作为判断三阴性乳腺癌预后的指标，但仍需要大样本的随机对照试验进一步证实，三阴性乳腺癌患者常规检测PARP1具有一定的临床意义。

Correlation between triple -negative breast cancer and PARP 1 expression:A Meta -a na lysis

Objective:To evaluate the clinical correlation between PARP1 expression and triple-negative breast cancer.Methods:We searched PubMed,CNKI,Wanfang Database and other searches to collect literatures about the PARP1 expression in triple-negative breast cancer.Statistical analyses were carried out by using RevMan 5 .2 soft-ware.Results:Five literatures of eligible studies involving 700 cases,which including 331 triple -negative breast cancer patients and 369 non triple-negative breast cancer patients,met the inclusion criteria.Results of the Meta-a-nalysis showed that the expression of PARP1 in triple-negative breast cancer was significantly different from that of non triple-negative breast cancer (OR=3.24,95%CI:1.45 ~7.23,P=0.004).Conclusion:The expression of PARP1 was positively correlated with triple -negative breast cancer.It may be used as an indication to judge the prognosis of triple-negative breast cancer patients,but it still needs a large sample of randomized controlled trials for further study.Triple-negative breast cancer patients with conventional detection of PARP1 expression has some clini-cal significance.