| ERCC1基因多态性与食管癌的研究进展 |
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| 引用本文： | 孙娟,成宏伟. ERCC1基因多态性与食管癌的研究进展[J]. 现代肿瘤医学, 2017, 0(7): 1141-1144. DOI: 10.3969/j.issn.1672-4992.2017.07.038 |
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| 作者姓名： | 孙娟 成宏伟 |
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| 作者单位： | 蚌埠医学院附属泰兴市人民医院消化内科,江苏 泰兴,225400 |
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| 摘 要： | 核苷酸切除修复交叉互补基因1(excision repair cross complementation 1,ERCC1)是核苷酸切除修复(NER)系统的关键酶,其表达情况与食管癌的发生发展及铂类耐药有关.检测ERCC1基因多态性有助于制定食管癌个体化治疗.
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| 关 键 词： | 核苷酸切除修复交叉互补基因1(ERCC1) 基因多态性 食管癌 |
ERCC1 gene polymorphisms and esophageal carcinoma |
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| Sun Juan,Cheng Hongwei. ERCC1 gene polymorphisms and esophageal carcinoma[J]. Journal of Modern Oncology, 2017, 0(7): 1141-1144. DOI: 10.3969/j.issn.1672-4992.2017.07.038 |
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| Authors: | Sun Juan Cheng Hongwei |
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| Abstract: | Excision repair cross complementation group 1(ERCC1)is a key enzyme of nucleotide excision repair sys-tem. The expression of ERCC1 is closely related to the development of esophageal carcinoma and resistance of plati-num - based chemotherapy. To detect ERCC1 polymorphism ERCC1 polymorphism might be benefited to the individu-alized chemotherapy for patients with esophageal carcinoma. |
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| Keywords: | ERCC1 gene polymorphisms esophageal carcinoma |
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