胸部放疗分割与局限期小细胞肺癌失败模式的相关性研究

目的：分析比较加速超分割与常规分割胸部放疗后局限期小细胞肺癌失败模式的差异。方法：回顾性调查我院2006年10月至2012年12月期间住院治疗的114例局限期小细胞肺癌患者病历资料，记录患者的治疗前临床特征、放疗分割方案、复发转移部位和放疗毒副反应。结果：局部／区域或远地转移作为首先失败模式和总体失败模式在常规分割组和超分割组的差异均无统计学意义（P ＞0．05）。超分割组中 II －III 级放射性肺炎和放射性食管炎的发生率均较常规分割组明显增高，其差异有显著统计学意义（P ＝0．006和 P ＝0．001）。结论：小细胞肺癌加速超分割胸部放疗未改变局部／区域复发和远地转移模式，但明显增加治疗毒性。加速超分割胸部放疗是否优于常规分割值得进一步研究。

Correlations between patterns of failure of small cell lung cancer and radiotherapy fraction

Objective:To explore the differences of patterns of failure (PoF)between conventional fraction (CF) thoracic radiotherapy (TRT)and accelerated hyper -fraction TRT (HF)in limited -stage small cell lung cancer (SCLC)patients.Methods:We retrospectively reviewed electronic database of SCLC in limited -stage patients trea-ted in our cancer center from October 2006 to December 2012.Clinical data was recorded including clinical features, TRT regimens,PoF,radiation toxicities.The endpoints of this study were the rates of local/regional (LR)recurrences and distant metastases (DM).Results:The differences of first failure patterns and /or overall failure patterns between two regimen groups were not statistically significant (P >0.05).There were more grade II -III thoracic toxicities in hyper -fraction group.Conclusion:Accelerated hyper -fraction TRT may be not superior to conventional TRT while increasing thoracic toxicity.