| PAK Group I的活性减弱促进肺癌细胞对EGFR-TKIs的敏感性 |
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| 引用本文： | 王斯,李苗,胡晶,杜峰,刘洋. PAK Group I的活性减弱促进肺癌细胞对EGFR-TKIs的敏感性[J]. 现代肿瘤医学, 2017, 0(9): 1361-1364. DOI: 10.3969/j.issn.1672-4992.2017.09.006 |
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| 作者姓名： | 王斯 李苗 胡晶 杜峰 刘洋 |
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| 作者单位： | 1. 中国医科大学基础医学院病原生物学教研室,辽宁 沈阳,110001;2. 北京市海淀区苏家坨镇社区卫生服务中心,北京,100194;3. 济宁医学院基础医学院病原生物学教研室,山东 济宁,272067;4. 中国医科大学基础医学院病理学教研室,辽宁 沈阳,110001 |
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| 基金项目： | 辽宁省教育厅科学研究一般项目(L2015583)，辽宁省科学计划项目(2013408001) |
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| 摘 要： | 目的:探讨p21活化激酶(p21-activated kinase,PAK)是否影响肺癌细胞对EGFR-TKIs的敏感性.方法:肺癌细胞系中加入PAK Group I抑制剂(IPA3)后,应用MTT、流式细胞术观察肺癌细胞的增殖能力.结果:IPA3和吉非替尼虽然能在不同程度上抑制肺癌细胞的增殖,但二者的联合用药能明显增强对肺癌细胞增殖的抑制作用.结论:PAK Group I的活性减弱后能抑制肺癌细胞的增殖,促进肺癌细胞对EGFR-TKIs的敏感性.
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| 关 键 词： | p21活化激酶 非小细胞肺癌 增殖 EGFR-TKIs 吉非替尼 |
The p21-activated kinase affects the sensitivity of lung cancer cell to epidermal growth factor receptor tyrosine kinase inhibitors |
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| Wang Si,Li Miao,Hu Jing,Du Feng,Liu Yang. The p21-activated kinase affects the sensitivity of lung cancer cell to epidermal growth factor receptor tyrosine kinase inhibitors[J]. Journal of Modern Oncology, 2017, 0(9): 1361-1364. DOI: 10.3969/j.issn.1672-4992.2017.09.006 |
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| Authors: | Wang Si Li Miao Hu Jing Du Feng Liu Yang |
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| Abstract: | Objective:To investigate the sensitivity of the p21-activated kinase(PAK)to EGFR-TKIs in NSCLC cells.Methods:The proliferation of lung cancer cells was observed by MTT assay and flow cytometry after adding PAK Group I inhibitor (IPA3)to lung cancer cell lines.Results:Although IPA3 and gefitinib could inhibit the proliferation of lung cancer cells in different degrees,and the combined use of IPA3 and EGFR-TKI(gefitinib)inhibited cell proliferation in an obvious manner.Conclusion:The decreased activity of PAK Group I can inhibit the proliferation of lung cancer cells and promote the sensitivity of lung cancer cells to EGFR-TKIs. |
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| Keywords: | p21-activated kinase non-smal cell lung cancer cell proliferation EGFR-TKIs gefitinib |
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