p63和 Ki67在 CIN 及宫颈癌组织中的表达及意义

目的：探讨 p63和 Ki67在 CIN 及宫颈癌组织中的表达及临床病理意义。方法：采用免疫组化技术（SP 法）检测 p63和 Ki67在30例正常宫颈组织和115例宫颈 CIN 和宫颈癌中的表达。结果：p63和 Ki67在正常宫颈黏膜上皮、CIN I、CIN Ⅱ级、CINⅢ级、浸润癌表达的阳性率分别为6．7％、40．0％、44．0％、76．0％、97．8％和6．7％、35．0％、44．0％、80．0％、100．0％。各级 CIN 与浸润癌相比 p63及 Ki67的表达率差异显著（P＜0．05）；在 CIN 和宫颈癌中 p63的表达与 Ki67的表达呈正相关（P ＜0．05）。p63和 Ki67表达率与临床分期及病理分级有关（P ＜0．05）。结论：p63和 Ki67可作为反映宫颈上皮增生病变程度及生物学行为的指标，对宫颈非浸润性病变与浸润性病变的诊断及鉴别有参考价值。

Expression and significance of p63 and Ki67 in cervical intraepithelial neoplasia(CIN) and cervical cancer

Objective:To study the expression and clinical significance of p63 and Ki67 in cervical intraepithelial neoplasia(CIN)and cervical cancer.Methods:Immunohistochemistry SP method was used to detect the expression of p63 and Ki67 in 115 cases of CIN and cervical cancer and 30 cases of normal cervical tissues.Results:The positive expression rate of p63 and Ki67 in normal cervical epithelium,CIN I,CIN Ⅱ,CIN Ⅲ and cervical invasive cancer were 6.7%,40.0%,44.0%,76.0%,97.8% and 6.7%,35.0%,44.0%,80.0%,100.0% respectively.The posi-tive expression rate of p63 and Ki67 was significantly different between CIN and infiltrating carcinoma(P <0.05). The expressions of p63 and Ki67 had a positive correlation between CIN and cervical cancer(P <0.05).The positive expression of p63 and Ki67 were closely correlated with clinical stage and pathological grade of cervical cancer(P<0.05).Conclusion:p63 and Ki67 might be used as markers for aggressive biological behaviour in cervical cancer, and might be useful to distinguish CIN and cervical cancer.