| 记忆性干细胞样T细胞在肿瘤治疗应用中的研究进展 |
| |
| 引用本文： | 邵洁,刘宝瑞.记忆性干细胞样T细胞在肿瘤治疗应用中的研究进展[J].现代肿瘤医学,2017(8):1318-1321. |
| |
| 作者姓名： | 邵洁 刘宝瑞 |
| |
| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤中心,江苏南京,210008 |
| |
| 基金项目： | 国家自然科学基金赞助项目(81220108023)，南京市医学科技发展重点项目(ZKX15012) |
| |
| 摘 要： | 记忆性干细胞样T细胞(stem memory T cells,TSCM)是最近几年发现的一个细胞亚群,约占外周血中总的CD4+T细胞和CD8+T细胞的2％～4％,是记忆性T细胞的早期分化阶段,具有记忆性细胞和干细胞的特点,基因谱介于初始T细胞和中央记忆T细胞之间.记忆性干细胞样T细胞具有自我更新和长期存活能力,这些特点使它们成为肿瘤领域关注的热点.本文将简述记忆性干细胞样T细胞的一些特点,以及它们在肿瘤治疗中的应用.
|
| 关 键 词： | 初始T细胞 记忆性T细胞 干细胞 记忆性干细胞样T细胞 |
Research progress of stem memory T cells in tumor therapy |
| |
| Shao Jie,Liu Baorui.Research progress of stem memory T cells in tumor therapy[J].Journal of Modern Oncology,2017(8):1318-1321. |
| |
| Authors: | Shao Jie Liu Baorui |
| |
| Abstract: | Stem memory T cells (TSCM) have been described in humans,constituting approximately 2％ ～ 4％ of the total CD4 + and CD8 + T-cell population in the periphery.TSCM represent the earliest developmental stage of memory T cells,displaying memory and stem cell-like properties,and exhibiting a gene profile between naive andcentral memory T cells.Their self-renewal capacity and long-term survival have sparked interest in the cancerfields.In this article,we will briefly summarize some characteristics of memory stem cell like T cells,and their application in tumor immunotherapy. |
| |
| Keywords: | naive T cells memory T cells stem cells stem memory T cells |
| 本文献已被 万方数据 等数据库收录！ |
|
