乳腺癌前哨淋巴结活检研究进展

近年来，乳腺癌的发病率越来越高，乳腺癌治疗方式也在不断改进，但手术仍然是早期乳腺癌治疗的主要手段。对于早期乳腺癌，前哨淋巴结活检术（sentinel lymph node biopsy，SLNB）是一种安全、精确的手术方式，已逐渐替代腋窝淋巴结清扫术（axillary lymph node dissection，ALND）成为早期乳腺癌治疗的标准术式。随着研究的深入，SLNB的应用范围更广，术后生活质量显著改善，但其操作尚需要进一步统一规范。在前哨淋巴结微转移、宏转移、前哨淋巴结活检阳性的老年患者以及新辅助化疗的前哨淋巴结活检等方面尚未达成共识，还需要更多大型多中心前瞻性的随机试验来进一步论证。

Research progress of sentinel lymph node biopsy in breast cancer

Recently,the incidence of breast cancer increasingly higher,the treatment of breast cancer has also been improved,but surgery is still the primary mean of treatment to early breast cancer.For the early breast cancer,sentinel lymph node biopsy (SLNB)is a safe and accurate surgical approach.It has gradually replaced axillary lymph node dissection (ALND)and become the standard surgical treatment for the early breast cancer.With further research,the range of SLNB applications wider,the quality of life after surgery is significantly improved,but the operation still needs to be further standardized.micrometastases and macrometastasis in sentinel lymph nodes,elderly patients with positive sentinel lymph node biopsy and neoadjuvant chemotherapy and other aspects have not yet reached a consen-sus,but also need more large-scale multicenter prospective randomized trials to further demonstrate.