Prolonged survival in a nasopharyngeal carcinoma patient with multiple metastases: a case report and review of the literature |
| |
Authors: | Chou CW; Liu JM; Wu MF; Li AF; Tie CM; Chi KH |
| |
Institution: | Department of Chest Medicine, Veterans' General Hospital-Taipei, Taiwan. |
| |
Abstract: | Nasopharyngeal carcinoma is a common cancer in South East Asia. In the
early stages, radiotherapy alone may achieve sustained control, but once
metastasis occurs, it becomes an incurable disease with limited survival
time. We report a case of nasopharyngeal carcinoma, initial stage T4N0M0,
diagnosed in 1985 in a patient aged 36 years who received 70 Gy
radiotherapy to the head and neck region. In 1988, relapse occurred with
multiple lung metastases. The patient received many chemotherapy regimens
with a very good response, including near complete remission with the first
treatment regimen of cisplatin, 5-fluorouracil and leucovorin for lung
metastases, and with the fifth chemotherapy regimen of ifosfamide as a
single agent. After ifosfamide treatment, there was residual fibrotic
change in the lung and complete disappearance, lasting for almost a year,
of the liver and bone lesions. The patient eventually died in July 1995 due
to progressive disease. Prolonged survival after mainly thoracic metastasis
is possible in patients with nasopharyngeal carcinoma, especially if the
tumor is chemo-responsive.
|
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|