应用ROC曲线分析SCC—Ag在早期食管癌诊断中的价值

目的：应用ROC曲线（receiveroperatingcharacteristiccurve）分析SCC—Ag在早期食管癌诊断中的价值。方法：用酶联免疫（enzyme—linkedimmunosorbentassay，ELISA）法检测40例正常体检者和100例I—II期食管癌患者血清中SCC—Ag水平，应用ROC曲线进行分析。结果：早期食管癌患者SCC—Ag水平高于正常组，差异有统计学意义（p〈0．000）；当SCC—Ag截断值为≥1．39ng／ml，此截断值的灵敏度为92．0％，特异度为94．0％，诊断符合率为92．6％；曲线下面积为：0．973，P=0．000，95％CI：0．952-0．994，SCC-Ag曲线下面积AUC（areundercurve）为0．748，P=0．000，95％CI：0．636—0．860，为食管癌最佳临床诊断临界点。结论：SCC—Ag水平变化可作为诊断早期食管癌的重要诊断依据。

The value of SCC- Ag in diagnostic early esophageal cancer By ROC curve analysis

Objective ： To explove the diagnostic significance ofSCC- Ag in early esophageal cancer By ROC curve. Methods ： Serum SCC-Ag level was detected with enzyme-linked immunosorbent （ELISA）in 100 I-II patients with esophageal cancer surgery and 50 cases with normal physical examination,Analysis of the application of ROC curve.Results ： SCC-Ag level in early esophageal cancer patients was higher than that of the normal group, and the difference was statistically significant （p 〈0.000）, When the SCC-Ag cutoff value is ≥ 1.39 ng/ml, It is the best chnical diagnosis of esophageal cancer critical point.the sensitivity of the cutoff value was 92%, the specificity was 94%, the diagnostic coincidence rate was 92.6%; the area under the curve 0.973, P=0.000, 95%CI：0.952-0.994, the area under SCC-Ag curve of AUC （are under curve） was 0.748, P= 0, 95%CI：0.636-0.860. Conclusions ： The change of SCC-Ag level can be used as an important diagnostic basis for early esophageal cancer.