132株耐甲氧西林金黄色葡萄球菌的临床分布及耐药性变迁分析

目的：了解本院临床标本中分离出的耐甲氧西林金黄色葡萄球菌（MRSA）的科室分布及耐药性变迁情况。方法：收集本院2009年1月-2011年1月共3年间临床分离到的MRSA，统计分析MRSA的分布及药敏试验结果。结果：3年内共分离出金黄色葡萄球菌（SA）249株，其中MRSA132株。分离出SA的标本中以呼吸道标本为主，占51．5％，其次为分泌物和脓液。检出率较高的科室是外科，占36．9％，其次为呼吸内科和老年科。除万古霉素、利福平、复方新诺明及呋喃妥因外，MRSA对其余的抗茵药物的耐药率均高于MSSA（对甲氧西林敏感金黄色葡萄球菌），耐药率均保持在40％以上，而且耐药率呈逐年上升趋势。结论：MRSA对大部分抗菌药物仍维持较高的耐药率，应定期监测临床标本中分离的MRSA耐药率，合理使用抗茵药物，延缓临床株耐药性的增长，控制医院感染的发生及暴发流行。

Clinical distribution and drug resistance variance analysis of 132 strains of methicillin-resistant Staphylococcus aurus

Objective ; to study the isolated methicillin resistant Staphylococcus aureus （MRSA）clinical specimens in our hospital （MRSA） and section of the distribution and drug resistance situation. Methods ： we collected from 2009January to 2011 January a total of 3 clinical isolates of MRSA, statistical analysis on resistance of MRSA distribution and drugsusceptibility test results.Results ： of 3 years were isolated from Staphylococcus aureus （SA） of 249 strains, the strain MRSA 132. SA isolated from specimens in respiratory specimens, accounting for 51.5%, followed by secretionand pus. The detection rate is higher in Department ofsurgery, accounting for 36.9%, followed by respiratory department of internal medicine and Department of geriatrics. In addition to vancomycin vancomycin, rifampin,cotrimoxazole and nitrofurantoin, MRSA resistant to antimicrobial agents and the rest of the ratio of MSSA（methicillin sensitive Staphylococcus aureus）, the resistance rate remained at more than 40%, and theresistance rate is rising year by year. Conclusions ; MRSA for most antibiotics remain high resistance rate, MRSA resistance should be separated and regular monitoring ofclinical specimens of rate, the rational use of antimicrobial drugs, delaying clinical strains of growth, control the incidence of nosocomial infection and outbreak.