Effect of a new antitumor drug cycloplatam on DNA structure and production

The new antitumor drug cycloplatam [amine (cyclopentylamine)-S-(-)-malatoplatinum(II)] caused dose-dependent formation of interstrand DNA ligationsin vitro depending on the duration of incubation. Like cisplatin, cycloplatam caused a deep and long inhibition of DNA production in tumor cells. The effect of cycloplatam in bone marrow and small intestine epithelium cells was weaker and shorter than that of cisplatin. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 197–199, February, 1998