Neurologic Sequelae Following Interferon Therapy of Juvenile Laryngeal Papilloma |
| |
| Authors: | TIMO VESIKARI AULI NUUTILA KARI CANTELL |
| |
| Affiliation: | Department of Paediatrics, Tampere University Central Hospital and the Central Hospital of Etelä-Pohjanmaa, and the Virus Department, the National Public Health Institute, Helsinki, Finland |
| |
| Abstract: | ABSTRACT. Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2-year-old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found. |
| |
| Keywords: | interferon therapy juvenile laryngeal papillomatosis neurotoxicity diplegia |
|
