| 肿瘤坏死因子β基因多态性与膀胱移行细胞癌的相关性研究 |
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| 引用本文： | 魏广金,李启忠,宋娟,王向阳,赵全兵. 肿瘤坏死因子β基因多态性与膀胱移行细胞癌的相关性研究[J]. 河南医学研究, 2008, 17(1): 26-28 |
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| 作者姓名： | 魏广金 李启忠 宋娟 王向阳 赵全兵 |
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| 作者单位： | 1. 新乡医学院临床医疗系,河南新乡,453003
2. 河南省人民医院泌尿外科,河南新乡,450003 |
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| 摘 要： | 目的:探讨肿瘤坏死因子β(tumor necrosis factor,TNF-β)基因多态性与膀胱移行细胞癌易感性的关系。方法:采用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)技术对膀胱移行细胞癌患者75例及正常对照52例的TNF-β基因的单碱基突变多态性进行分析。结果:膀胱移行细胞癌患者的TNF-β*2等位频率(40.7%)较正常人(24.0%)明显升高,存在显著性差异(P<0.05)。结论:TNF-β*2等位基因的频率升高与膀胱移行细胞癌的易患性有着一定的关系。
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| 关 键 词： | 肿瘤坏死因子 基因多态性 膀胱移行细胞癌 |
| 文章编号： | 1004-437X(2008)01-0026-03 |
| 修稿时间： | 2008-02-15 |
Association of TNF beta polymorphism with transitional cell carcinoma of bladder |
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| WEI Guang-jin,LI Qi-zhong,SONG Juan,WANG Xiang-yang,ZHAO Quan-bing. Association of TNF beta polymorphism with transitional cell carcinoma of bladder[J]. Henan Medical Research, 2008, 17(1): 26-28 |
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| Authors: | WEI Guang-jin LI Qi-zhong SONG Juan WANG Xiang-yang ZHAO Quan-bing |
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| Affiliation: | WEI Guang-jin1; LI Qi-zhong2; SONG Juan1; WANG Xiang-yang2; ZHAO Quan-bing1(1.Department of Clinical Medicine; Xinxiang Medical College; Xinxiang 453003; China; 2.Department of Urology; The People s Hospital of Henan Province; Zhengzhou 450003; China); |
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| Abstract: | Objective: To investigate the relationship between the polymorphism of TNF beta and susceptibility to transitional cell carcinoma of bladder.Methods: The single base change polymorphism in TNF beta gene was detected among 75 patients with transitional cell carcinoma of bladder and 52 controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: The gene frequency of the TNF beta* 2(40.6%) was significantly higher in patients with transitional cell carcinoma of bladder than that in the normal controls(24.0%),there was significant difference(P<0.05).Conclusion: The increase of TNF beta*2 allelic frequency is associated with susceptibility to transitional cell carcinoma of bladder. |
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| Keywords: | Tumor necrosis factor Gene polymorphism Transitional cell carcinoma of bladder |
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