沙美特罗替卡松粉吸入剂对初入高海拔地区青年脑体-心理生理能力的影响

目的探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年脑体-心理生理能力的影响,为促进高原习服提供新的措施,预防和治疗急性高原病。方法将34名受试者随机分为沙美特罗组(n=18)和对照组(n=16),自海拔1400m历时5d进入5200m,从进入海拔5200m当天开始,沙美特罗组每天早晚各1次吸入沙美特罗替卡松粉1个剂量(沙美特罗100μg,丙酸氟替卡松200μg),连续5d;对照组用同样的方法吸入少量生理盐水。于吸入沙美特罗替卡松粉吸入剂第5天采用DDX-200型电脑多功能心理生理测试仪,进行脑体-心理生理能力检测。检测项目包括左右手交叉敲击和缺失记忆的简单测验。结果沙美特罗组较对照组比较,左右手交叉敲击依次为:总时间均为(10±0)s;总次数:89.96±19.04:75.21±17.12(次);正确次数:87.19±17.24:73.56±16.93(次);错误次数:1.38±0.62:2.81±2.21(次)。沙美特罗组较对照组比较,缺失记忆的简单测验结果:总次数均为(17±0)次;错误次数:1.45±0.93:2.56±1.48(次)。差异均有显著性意义(P<0.05)。结论在高原吸入沙美特罗替卡松粉吸入剂能显著提高移居者的脑体-心理生理功能,可以促进高原习服、预防和治疗急性高原病。

Effect of Salmeterol and Fluticasone Propinate Powder Inhalant on Brain-body Mental-physiology Capability of Young People at High Altitudes

Objective To explore the effect of almeterol and fluticasone propinate powder inhalant on brain-body mental-physiology capability of young people at high altitudes.Methods34 subjects were randomly divided into two groups,salmeterol group(n=18)and control group(n=16).They entered region at an elevation of 5 200 metres from 1 400 meters in 5 days.Experiment group inhaled one dose salmeterol(100 μg salmeterol and 200 μg fluticasone propionate)and control group inhaled placebo(0.9% sodium chloride)twice daily for 5 consecutive days.Both-hands-cross frequency and depl-memory test were done by type DDX-200 multifunction psychological machine on the fifth day.ResultsCompared with control group,Both-hands-cross frequency in experiment group were shown as follow:total numbers 89.96±19.0475.21±17.12;correct numbers87.19±17.2473.56±16.93;wrong numbers 1.38±0.622.81±2.21.Depl-memory test results were shown as follow:wrong numbers1.45±0.932.56±1.48,all had significant difference(P<0.05).ConclusionSalmeterol can improve mental and physiology capability of high altitude residents,promote high altitude acclimatization,prevent and cure acute high altitude sickness.