髓系／NK前体细胞急性白血病1例并文献复习

目的:提高对髓系/NK前体细胞急性白血病的认识.方法:报道1例髓系/NK前体细胞急性白血病资料,并复习文献,总结该病临床及实验室检查特点.结果:患者以腹部症状起病,肝脾显著肿大.流式细胞仪免疫表型分析HLA-DR( )、CD11c( )、CD11b( )、CD13( )、CD33( )、CD38( )、CD56( )、MPO( ).经两疗程CHOP方案化疗,骨髓象部分缓解,但是髓外浸润加重,后改用VDP方案,最终因出现感染、DIC、多器官功能衰竭而死亡.结论:急性NK细胞白血病具有独特的临床、组织病理学和免疫表型特征,对现有化疗不敏感,预后恶劣.

Myeloid/NK Cell Precursor Acute Leukemia——A Case Report and Literature Review

Objective:To identify the clinical and pathological features of myeloid/NK cell precursor acute leukemia.Methods:The characteristics of myeloid/NK cell precursor acute leukemia was discussed with report of a case and review of literatures.Results:A patient was referrd to our hospital because of abdominal symptoms and splenohepatomegalia.Flow cytometric analysis of leukemic cells revealed stainings for HLA-DR(+),CD11c(+),CD11b(+),CD13(+),CD33(+),CD38(+),CD56(+),MPO(+).Two courses of CHOP regimen was effective with partial bone marrow remission,but the extra bone marrow infiltrations were aggravated,then chemotherapy for ALL(VDP)was used.Finally the patient developed infection,DIC and multiple organ dysfunction syndrome,which led to his eventual death.Conclusions:Myeloid/NK cell precursor acute leukemia is a rare disease with distinctive clinical histopathologic,and immunophenotypic characteristics.Current treatments are ineffective for most of patients.