| BAG-1、p53表达与NSCLC新辅助化疗疗效分析 |
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| 引用本文： | 曾辉,龚晓成,韩建伟,许朝阳. BAG-1、p53表达与NSCLC新辅助化疗疗效分析[J]. 实用肿瘤杂志, 2014, 29(2): 169-172 |
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| 作者姓名： | 曾辉 龚晓成 韩建伟 许朝阳 |
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| 作者单位： | 1. 浙江大学医学院附属第二医院建德分院胸外科,浙江建德,311600
2. 浙江大学医学院附属第二医院建德分院病理科,浙江建德,311600 |
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| 摘 要： | 目的 探讨Ⅲ期非小细胞肺癌(NSCLC)患者BAG-1、p53蛋白表达与新辅助化疗疗效之间的关系.方法 通过免疫组织化学法检测57例Ⅲ期NSCLC患者BAG-1、p53蛋白表达水平,并研究上述指标的表达与新辅助化疗疗效之间的关系.结果 BAG-1的表达与NSCLC的分化程度有关(P＜0.05),BAG-1与p53蛋白的表达无相关性(r=-0.136,P＞0.05).BAG-1表达与新辅助化疗疗效无相关性(P＞0.05),p53表达与新辅助化疗疗效无相关性(P＞0.05),BAG-1与p53共同表达与新辅助化疗疗效无相关性(P＞0.05).结论 化疗前Ⅲ期NSCLC患者BAG-1与p53均表达阳性者较阴性者新辅助化疗有效率低,但差异无统计学意义.
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| 关 键 词： | 癌,非小细胞肺/药物疗法 化学疗法,辅助 载体蛋白质类 基因,p53 基因表达 治疗结果 免疫组织化学 |
Expression of BAG-1 and p53 in relation to efficacy of neo-adjuvant chemotherapy in patients with NSCLC |
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| Affiliation: | ZENG Hui, GONG Xiao-cheng, HAN Jian-wei, et al ( Department of Thoracic Surgery,The Second Affiliated Hospital Jiande Branch, Zhejiang University School of Medicine ,Jiande ,311600, China) |
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| Abstract: | Objective To investigate the relationship of the expression of BAG-1 and p53 and the efficacy of neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer （NSCLC）. Methods Fifty seven patients with stage III NSCLC receiving neo-adjuvant chemotherapy were enrolled in the study. The expression of BAG-1 and p53 was detected by immunohistochemistry and the correlation of the expression of BAG-1 and p53 and the response rate of chemotherapy was analyzed. Results The expression of BAG-1 was significantly correlated with the differentiated degree of NSCLC（P 〈0, 05 ）. The expression of BAG-1 and p53 was not correlated with each other（ r = - 0. 136,P 〉 0.05 ）. The expression of both BAG-I and p53 was not correlated with the efficacy of neo-adjuvant chemotherapy （ P 〉 0. 05 ）. Conclusion The expression of BAG-1 and p53 has no correlation with the response rate of neo-adjuvant chemotherapy in patients with stage III NSCLC. |
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| Keywords: | carcinoma, non-small-cell lung/drug therapy chemotherapy, adjuvant carrier proteins genes, p53 gene expression treatment outcome immunohistochemistry |
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