单核苷酸多态性与肺癌化疗疗效及预后相关研究进展

单核苷酸多态性（single nucleotide polymorphism，SNP），指基因组DNA序列中频率大于1％的单个核苷酸的变异，这种变异有时导致其编码的蛋白结构和功能发生改变，从而影响其生物学功能。在肿瘤治疗领域表现为不同SNP基因型患者对治疗发生不同的反应．目前SNP与非小细胞肺癌疗效相关研究的主要基因包括DNA切除修复基因、基质金属蛋白酶基因、凋亡相关基因、药物代谢相关基因、细胞周期渊控綦因等。我们就SNP与肺癌化疗的疗效以及预后的相关性进行了综述。

Progression on response and prognosis of lung cancer and single nucleotide polymorphism

Single nucleotide polymorphism(SNP)is the single base pair variation in genomic DNA that occurs in more than 1% of the general population.SNPs sometimes cause structural and functional changes in protein encoded by the gene.In the treatment of malignant tumors,SNPs may be key factors in determining responses and prognosis of the treatment.Main genes that have been studied on the correlation of SNP with response and prognosis after the treatment of non-small cell lung cancer include:DNA excision and repair gene,matrix metalloproteinase gene,apoptosis related gene,drug metabolism related gene,cell cycle control gene,etc.This review will focus on the advances in correlation of single nucleotide polymorphism with response and prognosis of lung cancer after chemotherapy.