胚胎发育不良性神经上皮肿瘤临床及病理分析

目的探讨胚胎发育不良性神经上皮肿瘤（DNT）的临床及病理特点.方法对近年来收治的5例DNT的临床症状和体征、影像学、电生理及病理学资料进行了回顾性分析.结果DNT典型的临床表现为难治性癫痫,绝大多数于20岁以前发病,男性多于女性.病变多位于幕上,影像学检查与其他低级别胶质瘤难以鉴别.5例均于全麻下行开颅肿瘤全切除术,术后癫痫发作消失,病理均证实为DNT.随访3个月-5年,无肿瘤复发.结论DNT是手术可治愈的良性病变,预后良好,无需放疗和化疗.

Clinical and pathological study of dysembryoplastic neuroepithelial tumor

Objective To discuss the clinical and pathological features of dysembryoplastic neuroepithelial tumor (DNT). Methods Analyzing 5 cases of DNT treated in recent years by reviewing their data of clinic, image, electrophysiology and pathyology. Results Refractory epilepsy is a typical clinical manifestation. It always attacks before 20 years old, more common in men than in women. Most lesions are located in supertentorial space and not easy to be distinguished from other low grade gliomas. S patients all have been practiced tumor complete resection via craniotomy under general anesthesia. Then epileptic attacks disappeared in 5 cases. DNT were verified by pathology. Follow-up surveys are from 3 months to 5 years without tumor recurrence. Conclusions DNT is a surgically curable benign tumor, radiotherapy and chemotherapy are contraindicated.