Ethylketocyclazocine decreases noradrenaline release and blood pressure in the rabbit at a peripheral opioid receptor |
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Authors: | H. Ensinger L. Hedler C. Schurr K. Starke |
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Affiliation: | (1) Pharmakologisches Institut der Universität, Hermann-Herder-Strasse 5, D-7800 Freiburg i. Br., Germany |
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Abstract: | Summary Rabbits were pithed and their sympathetic outflow was stimulated electrically via the pithing rod. Arterial blood pressure, heart rate, the endogenous plasma noradrenaline level, the plasma 3H-noradrenaline clearance and the noradrenaline release rate (the rate of entry of endogenous noradrenaline into the plasma) were determined. Ethylketocyclazocine 0.1 mg kg–1+0.02 mg kg–1 h–1 and 1 mg kg–1 + 0.2 mg kg–1 h–1 but not 0.01 mg kg–1+ 0.002 mg kg–1 h–1 decreased blood pressure, the endogenous plasma noradrenaline level and the noradrenaline release rate. The effects of ethylketocyclazocine 1 mg kg–1+ 0.2 mg kg–1 h–1 were antagonized by naloxone 1 mg kg–1 + 0.5 mg kg–1 h–1. Given alone, naloxone caused no change. It is concluded that ethylketocyclazocine inhibits action potential-evoked release of noradrenaline from postganglionic sympathetic neurones, and hence can lower blood pressure, by a peripheral effect, possibly mediated by opioid receptors at the terminal axons. |
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Keywords: | Pithed rabbit Blood pressure Noradrenaline release Ethylketocyclazocine Opioid receptors |
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