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ICOSL-augmented adenoviral-based vaccination induces a bipolar Th17/Th1 T cell response against unglycosylated MUC1 antigen
Institution:1. Departments of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA;2. Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA;3. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA;4. Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, USA;1. Department of Physiology & Pharmacology, Winston-Salem NC, USA;2. Neuroscience and Alcohol Research Training Programs Wake Forest School Medicine, Winston-Salem NC, USA;3. Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA;4. Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, USA;5. Vanderbilt-Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN, USA;6. Department Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA;1. lmmanuel Kant Baltic Federal University, 3 Botkin str., 236016 Kaliningrad, Russia;2. Institute of Clinical Immunology, 14 Ydrintsevskaya str., 630099 Novosibirsk, Russia;1. Laboratory of Molecular Genetics, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan;2. Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan;3. Translational Center for Marine Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan;4. Agriculture Biotechnology Research Center, National Cheng Kung University, Tainan 70101, Taiwan;5. University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan;6. Research Center of Ocean Environment and Technology, National Cheng Kung University, Tainan 70101, Taiwan;1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan;2. Japan Science and Technology Agency, PRESTO, Kawaguchi, Saitama 332-0012, Japan;1. Institute for Infectious Diseases and Zoonoses, LMU Munich, Germany;2. German Center for Infection Research (DZIF), Munich Partner Site, Germany;1. University of Michigan, Child Health Evaluation and Research (CHEAR) Center in the Department of Pediatrics and Communicable Diseases, and the Department of Health Management and Policy, 1415 Washington Heights, Ann Arbor, MI 48109, USA;2. Centers for Disease Control and Prevention, Center for Disease Surveillance, Epidemiology, and Laboratory Science; 1600 Clifton Road, N.E., MS E-52, Atlanta, GA 30029, USA;3. University of Michigan, Child Health Evaluation and Research (CHEAR) Center in the Department of Pediatrics and Communicable Diseases, and the Department of Health Management and Policy, 300 North Ingalls Building 6A14, Ann Arbor, MI 48109, USA
Abstract:
Keywords:Cancer vaccine  Adenoviral vectors  Inducible T cell costimulatory (ICOS) ligand  T helper 17 cells (Th17)  MUC1
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