Sero-prevalence of rubella among pregnant women in India, 2017 |
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| Affiliation: | 1. Christian Medical College, Vellore, Tamil Nadu, India;2. All India Institute of Medical Sciences, Jodhpur, India;3. Bangalore Medical College and Research Institute, Vanivilas Women and Children’s Hospital, Bengaluru, Karnataka, India;4. KEM Hospital, Pune, India;5. Postgraduate Institute of Medical Education and Research, Chandigarh, India;6. Tata Main Hospital, Jamshedpur, Jharkhand, India;7. National Institute of Virology, Bengaluru Unit, Bengaluru, India;8. National Institute of Virology, Pune, India;9. Indira Gandhi Institute of Child Health, Bengaluru, India;10. Indian Council of Medical Research, New Delhi, India;11. National Institute of Epidemiology, Chennai, India;1. National Certification Committee for Polio Eradication, New Delhi, India;2. National Certification Committee for Polio Eradication Secretariat, New Delhi, India;3. Ministry of Health and Family Welfare, New Delhi, India;4. SEARO WHO, New Delhi, India;5. National Polio Surveillance Project, New Delhi, India;1. Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, Omiya-ku, Saitama 330-8503, Japan;2. Japan Cancer Society, Tokyo, Japan;3. Screening Group, Early Detection and Prevention Section, International Agency for Research on Cancer, Lyon, France;4. Department of Integrated Science and Engineering for Sustainable Society, Chuo University, Tokyo, Japan;1. Department of Paediatrics, Hanoi Medical University, Hanoi, Viet Nam;2. Department of Paediatrics, Bachmai Hospital, Hanoi, Viet Nam;3. Department of Medical Education and Skill Laboratory, Hanoi Medical University, Hanoi, Viet Nam;4. Department of Microbiology, Bach Mai University Hospital, Hanoi, Viet Nam;5. National Hospital of Paediatrics, Hanoi, Viet Nam;6. Department of Paediatrics, Saint Paul Hospital, Hanoi, Viet Nam;7. National Centre for Immunisation Research and Surveillance (NCIRS), The Children''s Hospital at Westmead, NSW, Australia;8. Discipline of Paediatrics and Child Health, The Children''s Hospital at Westmead Clinical School, Sydney Medical School, The University of Sydney, NSW, Australia;9. Australian Paediatric Surveillance Unit (APSU), Sydney, NSW, Australia;1. Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;2. Epidemiology of Infectious Diseases, Sciensano, Brussels, Belgium;3. Department of Paediatrics, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;4. Department of Obstetrics-Gynecology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium;5. Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Belgium;6. Centre for Environmental Health and Occupational Health, School of Public Health, Université libre de Bruxelles (ULB), Belgium;7. Institute for Medical Immunology, Université libre de Bruxelles (ULB), Belgium;1. Specialist Grade II (Microbiology), NCDC, India;2. Specialist Grade II (Public Health), NCDC, India;3. Junior Microbiologist, GDDIC, India;4. Research Assistant (Microbiology), NCDC, India;5. Laboratory Assistant (Microbiology), NCDC, India;6. Laboratory Technician (Microbiology), NCDC, India;7. Technical Assistant, GDDIC, India;8. Addl. Director & HOD (Microbiology), NCDC, India;1. WHO Country Office, Hanoi, Viet Nam;2. Centers for Disease Control and Prevention, Atlanta, GA, USA;3. National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam |
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| Abstract: | BackgroundWe conducted a sero-survey among pregnant women attending antenatal clinics of six hospitals which also function as sentinel sites for CRS surveillance, to estimate the prevalence of IgG antibodies against rubella.MethodsWe systematically sampled 1800 pregnant women attending antenatal clinics and tested their sera for IgG antibodies against rubella. We classified sera as seropositive (titre ≥10 IU/ml), sero-negative (titre <8 IU/ml) or indeterminate (titre 8–9.9 IU/ml) per manufacturer's instructions. In a sub-sample, we estimated the titers of IgG antibodies against rubella. IgG titer of ≥10 IU/mL was considered protective.ResultsOf 1800 sera tested, 1502 (83.4%) were seropositive and 24 (1.3%) were indeterminate and 274 (15.2%) were sero-negative. Rubella sero-positivity did not differ by age group, educational status or place of residence. Three hundred and eighty three (87.8%) of the 436 sera had IgG concentrations ≥10 IU/mL.ConclusionThe results of the serosurvey indicate high levels of rubella sero-positivity in pregnant women. High sero-prevalence in the absence of routine childhood immunization indicates continued transmission of rubella virus in cities where sentinel sites are located. |
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| Keywords: | Rubella virus Sero-prevalence India |
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