Granulysin: A Novel Host Defense Molecule |
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| Authors: | Alan M Krensky Carol Clayberger |
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| Institution: | Department of Pediatrics, Stanford University, Stanford, CA, USA. Krensky@stanford.edu |
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| Abstract: | Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection. |
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| Keywords: | Antimicrobial biomarker cytotoxicity granulysin rejection transplantation |
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