Increases in mRNA levels for Talpha1-tubulin in the rat kindling model of epilepsy |
| |
| Authors: | Sato K Abe K |
| |
| Affiliation: | Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan. satokei@cc.okayama-u.ac.jp |
| |
| Abstract: | The expression of mRNA for Talpha1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Talpha1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
