实验性犬心肌梗塞和溶栓后再闭塞时血浆中GMP—140,TXB2的变化

本文采用放免法测定实验性犬心肌梗塞和溶栓后再闭塞时血浆中ＧＭＰ－１４０、ＴＸＢ２、６－Ｋ－ＰＧＦ１α的含量变化，并探讨其与心肌梗塞溶栓后再闭塞的关系。结果表明，在血栓形成时血浆中ＴＸＡ２稳定代谢产物ＴＸＢ２水平显著升高（ｐ〈０．０５），在溶栓后再闭塞率高（８７．５％）的非治疗组（Ｂ组）。在溶栓后４小时至溶栓后３天期间呈进行性升高（ｐ〈０．０１），而在再 埘经低（１６．７％）的ＡＰＩ０１３４治疗组（

CHANGES OF PLASMA GMP-140 AND TXB_2 LEVELS DURING EXPERIMENTAL CORONARY THROMBOSIS AND REOCCLUSION AFTER RECANALIZATION IN DOGS

Dynamic changes of plasma platelet membrane glucoprotein-140 (GMP-140) and TXB2 levels were measured with RIA during experimental coronary thrombosis and reocclusion after thrombolytic therapy in dogs. The results showed that in group B dogs (nontreated with platalet inhibitor) with high reocclusion rate (87.5), plasma TXB2 and GMP-140 levels were elevated during thrombosis and remained high within thirty days after thrombolytic therapy with urokinase. In group A (platelet inhibitor API0134 treated) with much lower reocclusion rate(16.7%), plasma TXB2 and GMP-140 also increased at the time of thrombosis but at 4 hours, three days and thirty days after thromblytic therapy these two parameters were significantly lower than those in group B. It was shown that plasma TXB2 and GMP-140 levels changed parellelty during thrombosis and reocclusion. Dynamic measuement of TXB2 and GMP-140 might help to predict vascullar reocclusion and provide diagnostic values clinically.