依那普利对糖尿病大鼠心肌超微结构的影响

目的 观察糖尿病大鼠心肌超微结构的动态变化及依那普利干预的效果.方法 成年雄性Wistar大鼠分为:对照组、糖尿病组及糖尿病 依那普利组(每日2mg/kg灌胃,4月).腹腔注射链脲佐菌素诱发糖尿病.分别于病程1,3,5月取其左心室组织块行透射电镜检查.结果 糖尿病大鼠心肌超微结构自病程1月出现异常,随病程延长逐渐加重,依那普利治疗后大鼠心肌损害有所减轻.结论 依那普利可改善糖尿病大鼠的心肌超微结构,这可能是ACEI类药物发挥糖尿病时心肌保护作用的病理机制.

Effect of enalapril on diabetic rat myocardial ultrastructure

Objective To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment. Methods Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection. Histological analysis of the left ventricular tissue was performed with transmission electron microscope 1, 3, and 5 months after establishment of diabetes. Results Onset of myocardial damages was observed 1 month after the development of diabetes in the rats with gradual time-dependent exacerbation. Enalapril treatment could partially reverse the myocardial destruction in the diabetic rats. Conclusion Enalapfil intervention may improve the ultrastructural pathology of the myocardium in diabetic rats, which is suggestive of the action mechanisms of angiotensin-converting enzyme inhibitors in myocardium preservation.