恶性肿瘤相关物质群在大肠癌辅助诊断中的临床价值

目的 探讨恶性肿瘤相关物质群(TSGF)在大肠癌诊断中的临床应用价值.方法 用生化比色法检测71例大肠癌患者、55例大肠良性肿瘤患者及100健康体检人员的血清中的TSGF浓度,并进行比较分析.结果 大肠癌组TSGF浓度/阳性率(浓度为63.5～98×103 U/L,平均浓度为81.5×103 U/L/71%)明显高于大肠良性肿瘤组[(浓度为(43～75)×103 U/L,平均浓度为57.2×103 U/L/7.4%)]及健康体检组[(浓度为(40.5～73)×103 U/L,平均浓度为55.7×103 U/L/3%)];TSGF的阳性率与患者的年龄、性别和肿瘤的分期无关;TSGF诊断大肠癌的敏感度为71%,高于密胚抗原的(43.7%).结论 血清TSGF对大肠癌的早期诊断敏感性高于密胚抗原,有助于大肠癌的辅助诊断,尤其是大肠癌早期的诊断.

Clinical value of tumor-associated growth factor detection in the diagnosis of colorectal carcinoma

OBJECTIVE: To investigate the diagnostic value of tumor-supplied growth factors (TSGF) in patients with colorectal carcinoma. METHODS: The serum content of TSGF was determined in 71 patients with colorectal carcinoma 71, 55 with benign tumor, and 100 healthy volunteers with colorimetry. RESULTS: TSGF concentration and its positivity rate were both significantly higher in colorectal carcinoma patients (81.5 x 10(3) U/L/71%) than in normal controls (55.7 x 10(3) U/L/3%) and patients with benign tumor (57.2 x 10(3)U/L/7.4%).TSGF positivity rate was independent of the patients' age, gender and stage of colorectal carcinoma. The diagnostic sensitivity of TSGF was 71% for colorectal carcinoma, higher than that of carcinoembryonic antigen (43.7%). CONCLUSION: TSGF is more sensitive than carcinoembryonic antigen for early diagnosis of colorectal carcinoma.