| 细胞间粘附分子和嗜酸细胞趋化因子在哮喘患儿血清中的表达及意义 |
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| 引用本文： | 齐静姣,张平,任新乐. 细胞间粘附分子和嗜酸细胞趋化因子在哮喘患儿血清中的表达及意义[J]. 临床医学, 2009, 29(4): 95-97 |
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| 作者姓名： | 齐静姣 张平 任新乐 |
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| 作者单位： | 河南科技大学医学院免疫学教研室,洛阳,471003;河南科技大学第三附属医院内科 |
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| 摘 要： | 目的探讨支气管哮喘患儿血清可溶性细胞间粘附分子-1（sICAM-1）、血管内皮细胞间粘附分子-1（sVCAM-1）、嗜酸细胞趋化因子（Eotaxin）水平的相关性及临床意义。方法采用ELISA双抗体夹心法对38例哮喘患儿和36例正常对照组儿童血清sICAM、sVCAM-1、Eotaxin进行检测。结果哮喘患儿血清sICAM-1、sVCAM-1、Eotax-in水平均较对照组显著升高（P〈0．01），而哮喘发作期患儿与缓解期患儿之间差异也具有统计学意义（P〈0．05），重度发作患儿较轻、中度发作升高明显（P〈0．05）。哮喘患儿血清sICAM-1、sVCAM-1水平与Eotaxin水平之间存在正相关（r=0．632，P〈0．01）。结论sICAM-1、sVCAM-1、Eotaxin参与了哮喘的病理过程，其水平的高低可能与哮喘病情的严重程度有关，可视为哮喘气道炎症诊断和观察病情活动性的重要指标。
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| 关 键 词： | 细胞间黏附分子-1 血管内皮细胞间黏附分子-1 嗜酸细胞趋化因子 支气管哮喘 |
Expression and clinical significance of intercellular adhesion molecules and eotaxin in serum of bronchi asthmatic children |
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| QI Jingjiao,ZHANG Ping,REN Xinle. Expression and clinical significance of intercellular adhesion molecules and eotaxin in serum of bronchi asthmatic children[J]. Clinical Medicine, 2009, 29(4): 95-97 |
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| Authors: | QI Jingjiao ZHANG Ping REN Xinle |
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| Affiliation: | QI Jingjiao ,ZHANG Ping ,REN Xinle(1.Department of Immunology,Medical College of Henan University of Science and Technology, Luoyang 471003, China ;2.Third Affiliated Hospital, Henan University of Science and Technology) |
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| Abstract: | Objective To explore relationships between serum levels of soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1) and eotaxin in children with bronchi asthma and their clinical significance. MethodsSerum sICAM-1,sVCAM-1 and eotaxin were detected in 38 asthmatic children and 36 normal children by sandwich ELISA.ResultsThe levels of sICAM-1,sVCAM-1 and Eotaxin were significantly higher in children with asthma than that in normal subjects(P<0.01).The levels in ast... |
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| Keywords: | Soluble intercellular adhesion molecule-1 Soluble vascular cell adhesion molecule-1 Eotaxin Bronchi asthma |
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