Metabolomics and Its Potential in Drug Discovery andDevelopment From TCM |
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| Authors: | Hang Chu Ai-Hua Zhang Ying Han and Xi-Jun Wang |
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| Institution: | National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China,National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China,National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China and National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China |
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| Abstract: | Metabolomics, an omic science in systems biology, is the comprehensive profiling of metabolic changes occurring in living systems and has
been widely used in the modern research of traditional Chinese medicine (TCM). TCM is a complex medical science, which reflects rich
philosophical dialectical thought, puts the human body into a large system for observation and keeps human in a healthy status. For TCM
aroused great interest in the whole world, herbs and Chinese medical formulae (CMF) as treatment methods have also been widely attention.
Metabolomics represents a powerful way that provides a dynamic drawing of the phenotype of biological systems via the research of
endogenous metabolites, and its methods are similar to those of TCM. This review summarizes the advantages of metabolomics, highlight the
key role of biomarkers for drug discovery and development of TCM. |
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| Keywords: | Metabolomics traditional Chinese medicine formulae biomarker drug discovery |
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