| Efficacy of Traditional Chinese Medicine in the Treatment of
Rash Caused by Epidermal Growth Factor Receptor Inhibitors:
A Frequency Statistics and Meta?Analysis |
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| 作者姓名： | Shu?Yue Zheng Hui?Juan Cui Yan?Mei Peng Qiang Li Wen Shen Jing?Yi Zhang Chen?Yao Sun Xu Zhang Ke?Xin Tan Xue?Jiao Jiang |
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| 作者单位： | a.Beijing University of Chinese Medicine, Beijing, China,b.Department of Integrative Oncology, China?Japan Friendship Hospital, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China,a.Beijing University of Chinese Medicine, Beijing, China and a.Beijing University of Chinese Medicine, Beijing, China |
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| 摘 要： | Objective: The aim of this study is to evaluate the efficacy of Traditional Chinese Medicine (TCM) in the treatment of rash caused by
epidermal growth factor receptor inhibitors (EGFRIs). Materials and Methods: Foreign language database (such as PubMed, Web of
Science, Cochrane Library, EMBASE) and Chinese language database (such as China National Knowledge Infrastructure, VIP Database
for Chinese Technical Periodicals VIP], Wangfang, CBM disc) were searched for all trials of TCM in the treatment of rash caused by
EGFRIs until January of 2019. We also looked through the references of relevant studies to supplement additional trials. The SPSS 25.0
was used for statistics of TCM with high frequency, and Review Manager 5.3 was used for meta-analysis. Results: A total of 22 studies
were included in the study. We selected TCM whose frequency were >3.0%. They were Lonicera japonica（金银花）, Licorice Roots
Northwest Origin（生甘草）, Cortex Dictamni（白鲜皮）, Radix Sophorae Flavescentis（苦参）, Schizonepeta（荆芥）, Saposhnikovia
Divaricate（防风）. The meta?analysis revealed that the efficacy of TCM in treating EGFRIs?related rash was better than that of Western
medicine or none. Conclusions: TCM could significantly relieve rash caused by EGFRIs, which is worth popularizing. Moreover, the
mechanism deserves to be further explored.
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