糖基化终末产物与动脉粥样硬化的关系

糖基化终末产物(AGE)的形成是糖尿病患者代谢记忆的一个关键因素。系列研究及国内外相关研究显示AGE促进了动脉粥样硬化病变区的炎症、氧化应激、凋亡、微钙化灶的形成,促使斑块由稳定向易损方向发展,最终趋于破裂、血栓形成,导致急性冠状动脉综合征等急性心脑血管事件的发生。文章从AGE的形成、来源、代谢、理化特性及其在炎症、脂质蓄积、凋亡、钙化中的作用机制等几个方面进行简要阐述,希冀为动脉粥样硬化斑块的形成发展机制及治疗策略提供一些新的观念。

The Relationship Between Advanced Glycation End-products and Atherosclerosis

The formation of advanced glycation end-products(AGE)is a key factor of metabolic memory in diabetic patients. The series of studies from ours and others indicated that AGE could promote inflammatory response, oxidative stress, apoptosis and micro-calcification formation in atherosclerotic lesions and accelerate the transition from stable plaque to vulnerable plaque, followed by plaque rupture, thrombogenesis and finally the occurrence of acute coronary syndrome. This paper elaborates the formation, source, metabolism, characterization of AGE and the mechanisms of AGE in inflammation response, lipid accumulation, apoptosis and calcification. We hope it can provide some new ideas for the mechanisms of atherosclerosis and therapeutic strategy.