青少年抑郁症磁共振静息态默认网络功能连接研究

目的：利用静息态功能磁共振技术，分析青少年抑郁症默认模式网络(DMN)的功能连接异常改变。 方法:收集青少年抑郁症患者22例符合《美 国 精 神 障碍诊断与 统 计 手 册 第 四 版》抑郁症诊断标准及与之匹配的正常对照组20例，采集磁共振静息态BOLD数据，选取后扣带皮层(PCC)作为感兴趣的种子点，分析默认网络内部功能连接异常脑区，并与临床量表进行相关性分析。 结果:与正常对照相比功能连接度增加脑区为颞中回、顶下小叶脑区。功能连接降低的脑区为前扣带皮层、内侧前额叶及背侧前额叶脑区；且腹内侧前额叶皮层与抑郁症量表评分存在相关关系。 结论: 青少年抑郁症默认网络内功能连接存在异常，且部分功能连接强度变化与其临床症状存在相关性。

A study on functional connection of default network in resting-State fMRI in adolescent depression

Objective: To use resting state functional magnetic resonance technology to analyze the abnormal changes in the functional connectivity of the default mode network (DMN) of depression in adolescents. Methods: Collect 22 cases of adolescent depression patients who meet the American Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV) diagnostic criteria for depression and 20 cases of normal control group matched with them, collect MRI resting state BOLD data, and select The posterior cingulate cortex (PCC) is used as the seed point of interest to analyze the internal function of the default network to connect abnormal brain areas, and to perform correlation analysis with the clinical scale. Results: Compared with the normal control, the brain areas with increased functional connectivity were the middle temporal gyrus and the inferior parietal lobule. The brain areas with decreased functional connectivity are the anterior cingulate cortex, the medial prefrontal lobe, and the dorsal prefrontal lobe; and the ventromedial prefrontal cortex has a correlation with the depression scale score. Conclusion: There are abnormal functional connections in the default network for adolescent depression, and some of the changes in the strength of functional connections are correlated with their clinical symptoms.