血管平滑肌细胞内质网应激与血管钙化的研究进展

血管钙化是指羟基磷灰石沉积于血管壁,由多因素参与及调控,类似于骨、软骨形成的主动生物学过程。内质网应激是机体内适应性调节反应,适当的内质网应激帮助维持内质网稳态,但过度的内质网应激会促进血管钙化的发生与发展。本文综述内质网应激尤其是未折叠蛋白反应在血管钙化中的潜在作用和分子机制,希望为血管钙化的防治提供新的思路。

Research progress of endoplasmic reticulum stress in vascular smooth muscle cell and vascular calcification

Vascular calcification refers to the deposition of hydroxyapatite in the vascular wall, which is involved and regulated by multiple factors, similar to the active biological process of bone and cartilage formation. Endoplasmic reticulum stress is an adaptive regulatory response in the the organism. Appropriate endoplasmic reticulum stress helps maintain endoplasmic reticulum homeostasis, but excessive endoplasmic reticulum stress will promote the initiation and progression of vascular calcification. This paper reviews the potential role and molecular mechanism of endoplasmic reticulum stress, especially unfolded protein response, in vascular calcification, hoping to provide new ideas for the prevention and treatment of vascular calcification.