| 长链非编码RNA在血管生成中的研究进展 |
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| 引用本文： | 孙敬辉,王承龙,陈可冀.长链非编码RNA在血管生成中的研究进展[J].中国动脉硬化杂志,2020,28(10):905-910. |
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| 作者姓名： | 孙敬辉 王承龙 陈可冀 |
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| 作者单位： | 中国中医科学院西苑医院国家中医心血管病临床医学中心,北京市 100091 |
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| 基金项目： | 国家自然科学基金(81874410) |
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| 摘 要： | 生理性的血管生成对于组织修复、机体平衡具有重要的作用,但异常的血管生成可诱发多种疾病,如癌症、缺血性心脏病、中风等。调节血管的生成对于诸多疾病的治疗具有重要意义,抗血管生成疗法已在某些疾病中显示了治疗意义,但促血管生成疗法仍然是一个难题。近年来,大量研究显示长链非编码RNA(lncRNA)在血管生成中扮演着重要的角色,通过调节异常的lncRNA,可以抑制或促进血管生成,这为治疗异常血管生成的相关疾病开辟了新的领域。
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| 关 键 词： | 长链非编码RNA 血管生成 内皮细胞 |
| 收稿时间： | 2019/6/25 0:00:00 |
| 修稿时间： | 2019/9/16 0:00:00 |
Research progress of long noncoding RNA in angiogenesis |
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| SUN Jinghui,WANG Chenglong,CHEN Keji.Research progress of long noncoding RNA in angiogenesis[J].Chinese Journal of Arteriosclerosis,2020,28(10):905-910. |
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| Authors: | SUN Jinghui WANG Chenglong CHEN Keji |
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| Institution: | National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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| Abstract: | Physiological angiogenesis plays an important role in tissue repair and body balance, but abnormal angiogenesis can induce a variety of diseases, such as cancer, ischemic heart disease and stroke. Regulation of angiogenesis is of great significance for the treatment of many diseases. Anti-angiogenic therapy has shown therapeutic significance in certain diseases, but pro-angiogenic therapy remains a difficult problem. In recent years, a large number of studies have shown that long noncoding RNA (lncRNA) plays an important role in angiogenesis. By regulating abnormal lncRNA, angiogenesis can be inhibited or promoted, which opens up a new field for the treatment of diseases related to abnormal angiogenesis. |
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| Keywords: | long noncoding RNA angiogenesis endothelial cell |
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