| 高密度脂蛋白结构、代谢和功能研究新进展 |
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| 引用本文： | 周黎,李俊宜,何平平,唐朝克.高密度脂蛋白结构、代谢和功能研究新进展[J].中国动脉硬化杂志,2020,28(10):911-916. |
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| 作者姓名： | 周黎 李俊宜 何平平 唐朝克 |
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| 作者单位： | 南华大学心血管疾病研究所 动脉硬化学湖南省重点实验室 动脉硬化性疾病湖南省国际科技合作创新基地 湖南省分子靶标新药研究协同创新中心,湖南省衡阳市 421001;南华大学护理学院,湖南省衡阳市 421001 |
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| 基金项目： | 国家自然科学基金资助项目(81570408,81770461)；湖南省自然科学基金项目(2018JJ3455)；湖南省教育厅优秀青年项目(18B274) |
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| 摘 要： | 高密度脂蛋白(HDL)主要由载脂蛋白A1(ApoA1)、脂质以及相关的调节因子组成,其结构及功能异常与心血管疾病的发生、发展密切相关。HDL主要通过胆固醇逆向转运途径将血管内皮下巨噬细胞内胆固醇运送至肝脏并排出,调节体内的脂质平衡。研究发现,心血管疾病患者体内HDL的结构及代谢方式发生变化,包括ApoA1的异常修饰、血清淀粉样蛋白A取代ApoA1、HDL运载的miRNA含量变化。本文就HDL的结构、代谢和功能进行综述,为脂质代谢相关疾病的诊断和治疗提供新的思路。
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| 关 键 词： | 高密度脂蛋白 载脂蛋白A1 血清淀粉样蛋白A 胆固醇逆向转运 动脉粥样硬化 老年性黄斑变性 |
| 收稿时间： | 2019/9/22 0:00:00 |
| 修稿时间： | 2020/2/24 0:00:00 |
New progress in the study of structure, metabolism and function of high density lipoprotein |
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| ZHOU Li,LI Junyi,HE Pingping,TANG Chaoke.New progress in the study of structure, metabolism and function of high density lipoprotein[J].Chinese Journal of Arteriosclerosis,2020,28(10):911-916. |
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| Authors: | ZHOU Li LI Junyi HE Pingping TANG Chaoke |
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| Institution: | Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China;School of Nursing, University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | High density lipoprotein (HDL) is mainly composed of apolipoprotein A1 (ApoA1), lipid and related regulatory factors. Its structural and functional abnormalities are closely related to the occurrence and development of cardiovascular diseases. HDL mainly transports cholesterol from the macrophages under the endothelium of blood vessels to the liver and expels it through the reverse cholesterol transport pathway, regulating the lipid balance in the body. It is found that the structure and metabolism of HDL have changed in patients with cardiovascular disease, including the abnormal modification of ApoA1, serum amyloid A instead of ApoA1 and the change of miRNA content carried by HDL. This article reviews the structure, metabolism and function of HDL, which provides a new way for the diagnosis and treatment of lipid metabolism related diseases. |
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| Keywords: | high density lipoprotein apolipoprotein A1 serum amyloid A reverse cholesterol transport atherosclerosis age-related macular degeneration |
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