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| 腺苷A1受体激动剂对缺血损伤的兔脊髓神经元凋亡的影响 | |
| 引用本文： | 孟珊珊,张铁辉,刘洪文,贾非,赵庆杰. 腺苷A1受体激动剂对缺血损伤的兔脊髓神经元凋亡的影响[J]. 卒中与神经疾病, 2011, 18(3): 162-164. DOI: 10.3969/j.issn.1007-0478.2011.03.010 |
| 作者姓名： | 孟珊珊 张铁辉 刘洪文 贾非 赵庆杰 |
| 作者单位： | 1. 哈尔滨医科大学附属第一医院大桥分院,150001 2. 牡丹江医学院红旗医院 3. 武警牡丹江市森林支队 |
| 摘 要： | 目的观察腺苷A1受体激动剂对脊髓缺血性损伤后的神经元凋亡的影响。方法建立兔脊髓缺血模型,给予腺苷A1受体激动剂(CPA),观察兔神经功能恢复,通过病理切片,计算脊髓前角正常神经元,再应用免疫荧光染色检测BCL-2表达水平,western-blot的方法观察caspase3、caspase9、BCL-2、BCL-X1、BAX、BAD表达水平。结果与DMSO组相比,CPA组兔神经功能明显改善。caspase3、caspase9、BCL-2、BCL-X1表达水平显著高于DMSO组,而BAX、BAD表达水平则明显降低。结论腺苷A1受体激动剂可能通过抑制神经元凋亡对脊髓缺血损伤发挥保护作用。 |
| 关 键 词： | 腺苷A1受体激动剂 脊髓缺血 神经元 |
Effect of adenosine A1 receptor agonist on apoptosis of neurons in spinal cord ischemia in rabbits |
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| Meng Shanshan,Zhang Tiehui,Liu Hongwen,et al.. Effect of adenosine A1 receptor agonist on apoptosis of neurons in spinal cord ischemia in rabbits[J]. Stroke and Nervous Diseases, 2011, 18(3): 162-164. DOI: 10.3969/j.issn.1007-0478.2011.03.010 | |
| Authors: | Meng Shanshan Zhang Tiehui Liu Hongwen et al. |
| Affiliation: | Meng Shanshan*,Zhang Tiehui,Liu Hongwen*,et al.*Daqiao Hospital,The First Affiated Hospital of Haerbin Medical University,Haerbin 150001 |
| Abstract: | Objective To investigate effect of adenosine A1 receptor agonist on neuron apoptosis in spinal cord ischemia.Methods Adenosine A1 receptor agonist,CPA,was used in spinal cord ischemia rabbit model.The recovery of neuron functions and the number of normal neurons in anterior horn of spinal cord were evaluated immunofluorescent staining was used to detect BCL-2 expression and western-blot was used to evaluate caspase3,caspase9,BCL-2,BCL-X1,BAX and BAD expression.Results More normal neurons in anterior horn of... |
| Keywords: | Adenosine A1 receptor agonist Spinal cord ischemia Neuron |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |