| 辛伐他汀对冠心病患者基质金属蛋白酶-9和C-反应蛋白的影响 |
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| 引用本文： | 李岩,葛静玲. 辛伐他汀对冠心病患者基质金属蛋白酶-9和C-反应蛋白的影响[J]. 中国误诊学杂志, 2004, 4(10): 1590-1591 |
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| 作者姓名： | 李岩 葛静玲 |
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| 作者单位： | 1. 中国医科大学附属第二医院,干诊科,辽宁,沈阳,110004
2. 中国医科大学附属第二医院,手术室,辽宁,沈阳,110004 |
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| 摘 要： | 目的 :观察辛伐他汀治疗稳定型心绞痛 ( SAP)、急性冠脉综合征 ( ACS)患者 4周后基质金属蛋白酶 - 9( MMP- 9)和 C-反应蛋白 ( CRP)的变化 ,以了解辛伐他汀治疗对斑块稳定性的影响。方法 :将 30例 SAP和 30例 ACS患者分为他汀治疗组和常规治疗组 ,测定治疗前后 MMP- 9和 CRP水平。结果 :经辛伐他汀治疗后 ,治疗组 MMP- 9和 CRP水平明显降低 ,与治疗前比较有统计学差异 ( P<0 .0 0 1)。结论 :辛伐他汀治疗可明显减轻炎症因子 MMP- 9和 CRP水平 ,可能有利于动脉粥样硬化斑块的稳定
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| 关 键 词： | 辛伐他汀 治疗 CRP MMP-9 基质金属蛋白酶-9 C-反应蛋白 冠心病患者 |
| 文章编号： | 1009-6647(2004)10-1590-02 |
| 修稿时间： | 2004-06-26 |
Effects of Simvastatin on Serum Matrix Metalloproteinases-9 and C-reactive Protein Levels in Patients of Coronary Heart Disease |
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| LI Yan,GE Jing ling. Effects of Simvastatin on Serum Matrix Metalloproteinases-9 and C-reactive Protein Levels in Patients of Coronary Heart Disease[J]. Chinese Journal of Misdiagnostics, 2004, 4(10): 1590-1591 |
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| Authors: | LI Yan GE Jing ling |
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| Abstract: | Objective:To observe the effects of simvastatin on matrix mata lloproteiases 9(MMP 9),c reactive protein(CRP) level in patients with stable an gina pectoris(SAP) and acute coronary syndrome(ACS). Methods:Thirty SAP and th irty ACS patients were randomly divided into either the simvastatin group or the control group. The levels of MMP 9 and CRP before and after treatment were detected.Results:After treatment with simvastatin,the levels of MMP 9 and CRP in both two groups significantly decreased (P<0. 001).Conclusion:Simvastatin decreased level of inflammatory factors in the patients of SAP and ACS, so it could benefit to atherosclerotic plaque stabilization. |
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| Keywords: | Gelatinase B/analysis C-reactive protein/analysis Simvastatin/therapeutic use Coronary disease/drug therapy |
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