| 诱导性多潜能干细胞的研究进展与应用 |
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| 引用本文： | Jiang XR,Lu SX. 诱导性多潜能干细胞的研究进展与应用[J]. 中国医学科学院学报, 2011, 33(4): 456-461. DOI: 10.3881/j.issn.1000-503X.2011.04.022 |
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| 作者姓名： | Jiang XR Lu SX |
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| 作者单位： | 中国医学科学院 北京协和医学院 肿瘤医院&肿瘤研究所国家分子肿瘤学重点实验室,北京,100021 |
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| 基金项目： | 国家自然科学基金,国家重点基础研究发展计划项目(973计划) |
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| 摘 要： | 分化成熟的体细胞可在体外被重编程为诱导性多潜能干细胞,后者具有与胚胎干细胞相似的自我更新能力和发育多潜能性,同时避免了免疫排斥和伦理问题.患者特异性的诱导性多潜能干细胞将成为再生医学、药物筛选和毒理测试的理想工具.
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| 关 键 词： | 诱导性多潜能干细胞 体细胞重编程 发育多潜能性 分化 |
Research advances in induced pluripotent stem cells |
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| Jiang Xing-ran,Lu Shi-xin. Research advances in induced pluripotent stem cells[J]. Acta Academiae Medicinae Sinicae, 2011, 33(4): 456-461. DOI: 10.3881/j.issn.1000-503X.2011.04.022 |
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| Authors: | Jiang Xing-ran Lu Shi-xin |
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| Affiliation: | JIANG Xing-ran,LU Shi-xin State Key Laboratory of Molecular Oncology,Cancer Institute & Hospital,CAMS and PUMC,Beijing 100021,China |
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| Abstract: | Differentiated somatic cells can be directly reprogrammed into induced pluripotent stem(iPS) cells in vitro.Similarly to embryonic stem(ES) cells,iPS cells have pluripotency to differentiate into all cell types and capability to self-renew themselves indefinitely.Without immune rejection and ethical issues,patient-specific iPS cells promise to be an ideal tool for regenerative medicine,drug screening,and toxicity testing. |
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| Keywords: | induced pluripotent stem cells somatic cell reprogramming pluripotency differentiation |
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