Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment |
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Authors: | Chann Lagadec Erina Vlashi Lorenza Della Donna YongHong Meng Carmen Dekmezian Kwanghee Kim Frank Pajonk |
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Affiliation: | (1) Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, 90095-1714 Los Angeles, CA, USA;(2) Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 8-684 Factor Building, Box 951781, 90095-1781 Los Angeles, CA, USA |
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Abstract: | Introduction Recent data indicate a hierarchical organization of many solid cancers, including breast cancer, with a small number of cancer initiating cells (CICs) that have the ability to self-renew and exhibit multi-lineage potency. We, and others, have demonstrated that CICs in breast cancer and glioma are relatively resistant to ionizing radiation if compared to their non-tumorigenic counterparts. However, the extent of the remaining self-renewing capacity of CICs after fractions of radiation is currently unknown. We hypothesized that CICs, in contrast to their non-tumorigenic counterparts, not only survive fractions of ionizing radiation but also retain the CIC phenotype as defined by operational means. |
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