Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid |
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| Authors: | Eldad Melamed Franz Hefti Richard J. Wurtman |
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| Affiliation: | Laboratory of Neuroendocrine Regulation Department of Nutrition and Food Science Massachusetts Institute of Technology Cambridge, Massachusetts 02139, U.S.A. |
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| Abstract: | Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid. |
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