Immunocytochemistry of neuronal and glial markers in retinoblastoma |
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| Authors: | G Terenghi J M Polak J Ballesta D Cocchia F Michetti D Dahl P J Marangos A Garner |
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| Institution: | (1) Department of Histochemistry, RPMS, Hammersmith Hospital, W12 London;(2) Istituto di Anatomia Umana Normale, Universita Cattolica del Sacro Cuore, Rome, Italy;(3) Department of Neuropathology, Harvard Medical School, Boston, Massachussets, USA;(4) Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA;(5) Department of Pathology, Institute of Ophthalmology, University of London, EC1 London, Great Britain |
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| Abstract: | Summary An immunocytochemical study of 30 retinoblastomas was carried out using antibodies to neuronal and glial markers. The tumours were found to react with antibodies to neuron-specific enolase (NSE), a marker for neuronal elements, and S-100 and glial fibrillary acidic protein (GFAP), both of which are proteins present in glia. Two distinct cell populations were found within the tumour: the first, composed of anaplastic tumour cells at various stages of differentiation, showed both NSE and S-100 immunoreactivity; the second cell type, which immunostained for S-100 and GFAP, resembled mature glial cells. The results of this study indicate that the retinoblastoma may arise from a pluripotential primitive cell partially retaining neuronal and glial characteristics. |
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| Keywords: | Immunocytochemistry GFAP NSE Retinoblastoma S-100 |
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