血清超敏C反应蛋白与肌钙蛋白Ⅰ在新生儿缺血缺氧性脑病中的变化及其意义

目的探讨超敏C反应蛋白（hs—CRP）、肌钙蛋白Ⅰ（cTnⅠ）在新生儿缺血缺氧性脑病（HIE）中的变化及其意义。方法利用全自动生化分析仪测定30例HIE和18例正常新生儿血清hs～CRP、cTnⅠ水平，并同时检测血清CK、CK—MB、LDH、ALT、AST。结果HIE新生儿急性期血清hs—CRP水平明显高于对照组（P〈0．05）；恢复期下降，与正常对照组差异无显著性（P〉0．05）。HIE新生儿急性期血清cTnⅠ水平明显高于对照组（P〈0．01）；恢复期cTnⅠ与正常对照组之间无明显差异（P〉0．05）。HIE新生儿急性期CK、CK—MB、LDH、AST、ALT均较正常新生儿升高；恢复期CK、CK—MB、ALT降低明显（P〈0．05），与正常对照组之间差异显著（P〈0．05）；LDH、AST降低不明显（P〉0．05），但与正常对照组比较差异仍显著（P〈0．05）。结论hs—CRP和cTnⅠ的动态变化与HIE的疗程相平行，能较敏感地反映HIE患儿病情程度及转归趋势，与血清酶学改变一起可作为了解HIE的疗效及病情监测的指标之一。

Alteration and Clinical Significance of Serum hs-CRP and cTnI Levels in Newborns with Hypoxic-ischemic Encephalopathy

Objective To investigate the changes of high-sensitivity C reactive protein(hs-CRP) and cardiac troponin I(cTnI) levels in newborns with hypoxic-ischemic encephalopathy(HIE).Methods Thirty infants with HIE and 18 healthy newborns were selected as study cases and controls respectively by automatic biochemistry analyzer.Serum hs-CRP and cTnI contents were measured by reaction rate method;and the activities of creatine kinase(CK),creatine phosphokinase iscenzyine(CK-MB),lactate dehydrogenase(LDH),alanine transaminase(ALT),and aspartate aminctransferasc(AST) were detected as well.Results The hs-CRP level in newborns with HIE at acute stage was significantly higher that that of the controls(P<0.05).The hs-CRP level in newborns with HIE at convalescent stage decreased,and there was no significant difference between the newborns with HIE and the controls(P>0.05).The cTnI level in newborns with HIE at acute stage was significantly higher than that of the controls(P<0.01),and there was no significant difference on the cTnI level at convalescent stage between the newborns with HIE and the controls(P>0.05).The values of CK,CK-MB,LDH,ALT,and AST in newborns with HIE at acute stage were higher than those in the controls;the values of CK,CK-MB,and ALT decreased significantly at convalescent stage(P<0.05),there were significant differences between the newborns with HIE and the controls(P<0.05).But the values of LDH and AST in newborns with HIE decreased insignificantly at convalescent stage(P>0.05),and there were still significant differences as compared with the controls(P<0.05).Conclusions The variation of hs-CRP and cTnI levels in newborns with HIE is paralleled to the course and severity of the disease,which can sensitively reflect the fate and prognosis of HIE.Therefore,hs-CRP and cTnI may be used as the vital indexes for evaluating curative effect and judging prognosis of HIE.