早产危险因素病例对照研究

目的 :了解早产的危险因素 ,为制定预防策略和措施提供科学依据 .方法 :采用成组病例对照研究 ,针对早产的5 5项可疑危险因素 ,对 95例早产产妇和 1 1 6例足月产产妇进行问卷调查 .结果 :单因素分析 ,得到 1 7项早产危险因素 ,经进一步多因素logistic回归分析发现产检次数过少 (OR =1 1 .8,95 %CI=3.7～ 37.4 )、暴露视频终端 (VDT)每日 >2 .5h (OR=4 .6 ,95 %CI=1 .6～ 1 3.2 )、孕期接触有毒化学物 (OR =76 .6 ,95 %CI=5 .7～ 1 0 32 .1 )、负性事件 (OR =2 0 .5 ,95 %CI=2 .5～ 1 70 .4 )、妊高征 (OR =7.6 ,95 %CI =2 .0～ 2 8.7)、妊娠合并贫血 (OR =4 .3,95 %CI=1 .4～ 1 3.4 )是早产的主要危险因素 .结论 :产前检查次数过少 ,孕期暴露VDT时间较长 ,孕期接触有毒化学物、负性事件、妊高征和妊娠合并贫血是早产的主要危险因素 .

A case-control study on risk factors for preterm delivery

AIM: To investigate the risk factors of premature delivery. METHODS: A case control survey was conducted on 55 possible risk factors in 95 preterm deliveries and 116 term deliveries from June 2002 to May 2003 in Xijing Hospital. RESULTS: A multiple logistic regression analysis found that out of the 55 factors under study, each of the following factors was independently correlated with the occurrence of preterm delivery: negative life events (odds ratio [OR]: 20.5, 95% confidence interval [CI]: 2.5-170.4), maternal anemia (OR: 4.3, 95% CI: 1.4-13.4), pregnancy induced hypertension (PIH) (OR: 7.6, 95%CI: 2.0- 28.7), the frequency of pre delivery obstetrical examination (OR:11.8, 95% CI: 3.7-37.4), exposure to toxic chemicals during gestation (OR: 76.6, 95% CI: 5.7-1032.1), and exposure to video display terminals (VDT) (OR: 4.6, 95% CI: 1.6-13.2). CONCLUSION: The above 6 factors are all main risk factors of premature.