| PELA-BSA微球体外释药的灰色数学模型与结果预测 |
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| 引用本文： | 任建敏,邹全明,王缚鲲,曾纬锟.PELA-BSA微球体外释药的灰色数学模型与结果预测[J].华西药学杂志,2002,17(5):332-333. |
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| 作者姓名： | 任建敏 邹全明 王缚鲲 曾纬锟 |
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| 作者单位： | 第三军医大学医学检验系,重庆,400038 |
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| 摘 要： | 目的：运用灰色数学理论预测长效缓释蛋白微球的体外释药过程。方法：以复乳法制备PELA蛋白微球作为实验对象，根据灰色数学模型，借助计算机编程，预测PELA蛋白微球的体外释药过程。结果：预测值与实测值平均绝对误差E在2.3-4.6之间，平均相对误差在9.2％-14％范围内。结论：灰色数学理论可用于预测长效缓释释药体系体外释药过程。
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| 关 键 词： | 灰色理论 微球 预测 |
| 文章编号： | 1006-0103(2002)05-0332-02 |
| 修稿时间： | 2002年6月1日 |
THE RELEASING MODEL OF PELA MICROSPHERES LOADED PROTEIN IN VITRO |
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| REN Jian-min,ZOU Quan-ming,WANG Fu-kun,ZEN Wei-kun Faculty of Medical Laboratory Science,The Third Military Medical University,Chongqing ,China.THE RELEASING MODEL OF PELA MICROSPHERES LOADED PROTEIN IN VITRO[J].West China Journal of Pharmaceutical Sciences,2002,17(5):332-333. |
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| Authors: | REN Jian-min ZOU Quan-ming WANG Fu-kun ZEN Wei-kun Faculty of Medical Laboratory Science The Third Military Medical University Chongqing China |
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| Institution: | REN Jian-min,ZOU Quan-ming,WANG Fu-kun,ZEN Wei-kun Faculty of Medical Laboratory Science,The Third Military Medical University,Chongqing 400038,China |
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| Abstract: | OBJECTIVE To predict drug release from the extended formulations by grey maths model. METHODS The grey maths model was constructed according to drug release data within shot time through computer processing and employed to forecast the BSA release from poly(D,L-lactide)-polyethylene glycol copolymer (PELA) microspheres in vitro , which were prepared by double emulsion evaporation method.RESULTS The absolute and relative errors between the factual and predicting values were 2.3 4.6 and 9.2% 14%, respectively. CONCLUSION Grey maths theory can be used to forecast drug release from the sustained and extended formulations. |
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| Keywords: | Grey maths theory Microsphere Prediction |
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