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Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization |
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| Authors: | Gunnar Blomqvist Albert Gjedde Mark Gutniak Valdemar Grill Lennart Widén Sharon Stone-Elander Eric Hellstrand |
| Institution: | (1) Department of Clinical Neurophysiology, Karolinsky Hospital, Box 60500, S-10401 Stockholm, Sweden;(2) Department of Endocrinology, Karolinsky Hospital, Box 60500, S-10401 Stockholm, Sweden;(3) Positron Imaging Laboratories, McConnell Brain Imaging Center, Montreal Neurological Institute, H3A2134 Montreal, Quebec, Canada;(4) Karolinska Pharmacy, S-10401 Stockholm, Sweden |
| Abstract: | The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62±19 (mean±SEM)  mol hg–1 min–1, and the half-saturation constant was found to be 4.1 + 2.3 mM.Offprint requests to: G. Blomqvist |
| Keywords: | Blood-brain transfer of glucose Hypoglycaemia Michaelis Menten Positron emission tomography |
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