高原高血压24h平均脉压与血浆内皮素1、一氧化氮关系的探讨

目的 探讨研究高原高血压患者24 h平均脉压与血浆内皮素1、一氧化氮的关系。方法 对35例患者均在未服药状态下进行动态血压监测,按24 h平均脉压≤60mmHg,60～69mmHg,70～79mmHg,80～89mmHg,90～99mmHg,≥100mmHg分为6组,同时测定各组的血浆内皮素1、一氧化氮的水平情况。结果 随着24 h平均脉压增高,血浆内皮素1水平增高,而一氧化氮水平降低。结论 高原高血压患者24h平均脉压与血浆内皮素1呈正相关,与一氧化氮水平呈负相关。

The Relation Between 24 Hours Average Pulse Pressure and the Serum Concentrations of Nitric Oxide and Endothelin in Patients with High Altitude Hypertension

Objective To investigate the relation between 24 hours average pulse pressure and the serum concentrations of NO and ET -1 in patients with high altitude hypertension. Methods The ambulatory blood pressure monitoring ( ABPM) was performed in thirty-five patients with high altitude hypertension and the 24 hours average pulse pressure (PP) were divided into six groups (≤60,60-69,70-79,80-89,90-99,≥100mmHg).The NO and ET-1 level in serum were measured in all group (35cases). Results The ET-1 level increased as the 24 hours average pulse pressure went up. But the levels of NO who on the contrary(P < 0.01). Conclusion 24 hours average pulse pressure of high altitude hypertension patients had positive correlation with the levels of ET-1. And it had negative correlation with the levels of NO.